Eligibility criteria
Condition
Rheumatoid Arthritis
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Clinical diagnosis of active seropositive rheumatoid arthritis on a stable dose of
methotrexate (7.5-25 mg weekly) for at least 12 weeks with or without a history of
anti-TNF use.
Exclusion criteria
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- Any prior use of rituximab or other B cell depleting agents.
- Any significant health problem other than rheumatoid arthritis
- Clinically significant laboratory abnormalities