Patients who had evidence of acute pharyngitis/tonsillitis based on erythematous pharyngeal
mucosa or thick exudate covering the pharynx and tonsillar area, and at least one of the
following signs or symptoms were included: sore/scratchy throat; pain on swallowing; chills
and/or fever cervical adenopathy; scarlet fever rash on the face and skin folds, or red
tongue with prominent papillae ("strawberry tongue"). Subjects were required to have a
positive rapid antigen detection test (RADT) or a positive culture of the pharynx or
tonsils for GABHS.
Patients were excluded if they had previously diagnosed disease(s) of immune function or
treatment with any systemic antibiotic within the previous 7 days.