Patients who had evidence of acute pharyngitis/tonsillitis based on erythematous
pharyngeal mucosa or thick exudate covering the pharynx and tonsillar area, and at least
one of the following signs or symptoms were included: sore/scratchy throat; pain on
swallowing; chills and/or fever cervical adenopathy; scarlet fever rash on the face and
skin folds, or red tongue with prominent papillae ("strawberry tongue"). Subjects were
required to have a positive rapid antigen detection test (RADT) or a positive culture of
the pharynx or tonsils for GABHS.
Patients were excluded if they had previously diagnosed disease(s) of immune function or
treatment with any systemic antibiotic within the previous 7 days.