- Hospitalized patients with psychosis
- Eligible for intramuscular treatment
- Miminum score of 60 on the PANSS, a score of 14 in the sum of PANSS excitation score
and a score of at least 4 in 1 of the following items: poor control of impulses,
tension, hostility, uncooperativeness or excitation.
- Treatment with antidepressants or mood stabilizers within seven days prior to the
enrollment; for monoamine oxidase inhibitors (MAOIs) and moclobemide, this period must
be two weeks; for fluoxetine, five weeks
- Resistance to conventional antipsychotic agents
- A history of epilepsy
- A diagnosis of abuse of substance within the previous 3 months according to the DSMIV
criteria.