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A Study To Evaluate The Efficacy Of Eplerenone Compared With Losartan For The Treatment Of Patients With Mild To Moderate Hypertension

Last updated on February 20, 2019

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Study Location
Pfizer Investigational Site
Kaohsiung, , Taiwan
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Hypertension
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- History of mild to moderate hypertension, or newly diagnosed hypertension, defined as
seDBP ≥90 mmHg and

- Withdrawal of all previous antihypertensives prior to the single-blind placebo run-in
period and the double-blind treatment period

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Secondary hypertension (e.g., renal, renovascular, or adrenocortical disease,
pheochromocytoma, Cushing's syndrome, primary aldosteronism, iatrogenic), severe
hypertension, or malignant hypertension

- The patient cannot withdraw from antihypertensives by any route including diuretics,
alpha-blockers, betablockers, calcium channel blockers, ACE-I, ARB, or other
medications affecting blood pressure; patients who have stable angina and have not had
their nitrate dosage changed within the past three months (i.e., on a stable
maintenance dose) are eligible for this study; sildenafil citrate, theophylline, or
papaverine must not be taken within 24 hours prior to a clinic visit

NCT00649311
Pfizer
Terminated
A Study To Evaluate The Efficacy Of Eplerenone Compared With Losartan For The Treatment Of Patients With Mild To Moderate Hypertension

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