- Awake unrestored or unrefreshed, associated with significant distress or impairment in
social, occupational, or other important areas of functioning during the daytime, for
at least 3 nights for the past 3 months prior to screening
- Self-report wake after sleep onset sleep onset
- PSG (Polysomnography) sleep criteria of wake after sleep onset persistent sleep
- MAP (Multivariable Apnea Risk index) index > or = 0.5 at screening
- BMI = or > 32 kg/m2
- History or presence of breathing related disorders
- PSG findings consistent with and periodic limb movement disorder, narcolepsy or other
dyssomnia or parasomnia including apnea-hypopnea index > 10/hr; or period limb
movement with arousal index > 10/hr.