- Generally healthy, postmenopausal women aged 40 - 75 years inclusive
- Intact uterus
- Last natural menstrual cycle (without exogenous hormone therapy) completed at least
12 consecutive months before screening
- A history or active presence of thrombophlebitis, thrombosis or thromboembolic
disorders
- A history or active presence of cerebrovascular accident, stroke, or transient
ischemic attack
- A history or active presence of malignancy, or treatment for malignancy, within the
previous 10 years
Additional criteria applies.