Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics

• Experimental: Hepatic Function - Mild Impairment
  
  Subjects with mild hepatic impairment (Child Pugh class A, score 5-6)
  Intervention: Drug: AG-013736
• Experimental: Hepatic Function - Moderate Impairment
  
  Subjects with moderate hepatic impairment(Child Pugh class B,score 7-9)
  Intervention: Drug: AG-013736
• Experimental: Hepatic Function - Normal
  

  Group 1

  1) subjects with normal hepatic function

  Intervention: Drug: AG-013736

Inclusion Criteria:

• Diagnosis of reduced hepatic function (Child Pugh Classification A or B)
• Body Mass Index of 18-32 kg/m2

Exclusion Criteria:

• History of febrile illness within 5 days prior to first dose
• Any condition possibly affecting drug absorption (e.g. gastrectomy)
• Positive urine drug screen