- Subjects who self report nonrestorative sleep but no problems either getting to sleep
or staying asleep
- Complaints of significant distress or impairment in social, occupational, or other
important areas of functioning during daytime for at least 3 nights per week
- Self reports sWASO (Wake after sleep onset) for
reports LPS (latency to persistent sleep onset ) for
(then neither PSG (polysomnography) screening night showing WASO >45min, or LPS > 20
minutes)
- Customary bedtime betw. 9 pm and midnight and rise between 4 and 9 AM
- Psychiatric disease or disorder as determined by current administration of the MINI
(Mini International Neuropsychiatric Interview)
- History or presence of any breathing-related sleep disorder, narcolepsy, or any other
dyssomnias or any parasomnia, or restless legs syndrome MAP > 0.5 at screening
- History or presence of any medical or neurological condition that could interfere with
sleep (chronic pain, Restless leg, etc)
- Current use of meds wth known psychotropic effects or known or suspected effects on
sleep
- Alcohol or substance abuse (unless in remission for at least a year
- Excessive caffeine use (or any use after 6 pm for at least 3 months
- Regular napping or any naps after 6 pm
- Excessive cigarette or cigar smoking over the last 3 months
- no participation in an investigational new drug study within 30 days of screening, and
no previous participation in a study of PD200390
- No night or rotating shift work