- Advanced solid tumors, histologically proven at diagnosis which is refractory to
standard of care or for whom no standard of care therapy is available
- Adequate blood cell counts, normal kidney function, and performance status of 0 or 1
- Major surgery, radiation therapy or anti-cancer therapy within 2 weeks of starting
study treatment
- Prior stem cell transplant
- Active or unstable cardiac disease or heart attack within 12 months of starting study
treatment