1. Men aged 20 to 45 years, or greater than 65 years, inclusive, at screening and who
agree to use a medically acceptable form of contraception during the study and to
continue its use for 12 weeks after test article administration.
2. Healthy as determined by the investigator on the basis of medical history, physical
examination, clinical laboratory tests, vital sign measurements and 12-lead
1. Presence or history of any disorder that may prevent the successful completion of the
2. Any history or presence of chronic respiratory disorder or disease including but not
limited to asthma, sleep apnea, or chronic obstructive pulmonary disease (COPD).