Study Evaluating Safety of GSI 136 in Young and Elderly Japanese Males

• Alzheimer Disease
• Healthy

• Drug: GSI 136
• Drug: placebo

• Experimental: GSI 136
  
  Intervention: Drug: GSI 136
• Placebo Comparator: placebo
  
  Intervention: Drug: placebo

Inclusion Criteria .

1. Men aged 20 to 45 years, or greater than 65 years, inclusive, at screening and who agree to use a medically acceptable form of contraception during the study and to continue its use for 12 weeks after test article administration.
2. Healthy as determined by the investigator on the basis of medical history, physical examination, clinical laboratory tests, vital sign measurements and 12-lead electrocardiogram (ECG).

Exclusion Criteria

1. Presence or history of any disorder that may prevent the successful completion of the study.
2. Any history or presence of chronic respiratory disorder or disease including but not limited to asthma, sleep apnea, or chronic obstructive pulmonary disease (COPD).