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A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

Last updated on March 14, 2019

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Study Location
Roswell Park Cancer Institute
Buffalo, New York, 14263 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Advanced Malignant Solid Tumors
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Patients with a histologically or cytologically confirmed advanced malignant solid
tumor for which there is no currently approved treatment or which is unresponsive to
currently approved therapies;

- Eastern Cooperative Oncology Group (ECOG) performance status 0-1. Patients with
performance status 2 could be eligible upon agreement between sponsors and
investigators;

- Adequate bone marrow, renal, liver and cardiac functions;

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- History of Interstitial Lung Disease (ILD).

- Drugs with known CYP2D6 inhibitory effects

- Drugs that are highly dependent on CYP2D6 for metabolism.

- Women who are pregnant or breastfeeding.

NCT00728468
Pfizer
Completed
A Study To Test The Impact Of PF- 00299804 On How The Body Handles Dextromethorphan In Cancer Patients

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[email protected]

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