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Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease

Last updated on February 23, 2019

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Study Location
Pfizer Investigational Site
Glendale, California, 91206 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Alzheimer's Disease
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
50 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Male or female (of non-child bearing potential) subjects ages ≥50 years of age.

- Diagnosis of probable AD (of mild to moderate severity), consistent with criteria from
both: NINCDS-Alzheimer's Disease and Related Disorders Association (ADRDA) and
DSM-IV-TR.

- MMSE score of 16-26 inclusive.

- Rosen-Modified Hachinski Ischemia Score ≤4.

- On a stable dose of background cholinesterase inhibitors or memantine for at least 60
days prior to dosing.

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details

- Diagnosis or history of other dementia or neurodegenerative disorders.

- Diagnosis or history of clinically significant cerebrovascular disease.

- Specific findings on magnetic resonance imaging (MRI); cortical infarct, micro
hemorrhage, multiple white matter lacunes.

- History of allergic or anaphylactic reactions.

NCT00733642
Pfizer
Completed
Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease

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Questions about a trial? Call or email to reach a Pfizer Clinical Trial Contact Center

Pfizer Clinical Trials Contact Center

1-800-718-1021

[email protected]

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Contact a representative by phone, email, or visiting the study website. Please see the references below:

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Pfizer Clinical Trials Contact Center

1-800-718-1021

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[email protected]

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