Study Comparing the Efficacy of Two Ibuprofen Formulations

• Drug: placebo
  
  2 placebo gels capsules delivered as a single dose.
• Drug: ibuprofen Formulation 1
  
  2 marketed ibuprofen gels
• Drug: ibuprofen Formulation 2
  
  2 marketed ibuprofen gels

• Placebo Comparator: 1
  
  Intervention: Drug: placebo
• Active Comparator: 2
  
  Intervention: Drug: ibuprofen Formulation 1
• Active Comparator: 3
  
  Intervention: Drug: ibuprofen Formulation 2

Inclusion criteria :

• Outpatients with post-operative pain following surgical extraction of third molars,
• examined by the attending dentist or physician and medically cleared to participate in the study,
• in general good health and have no contraindications to the study or rescue medication.

Exclusions criteria:

• any serious medical condition,
• acute localized dental infection at the time of surgery ,
• females who are pregnant, lactating, of child-bearing potential, or post-menopausal for less than 2 years and not using a medically approved method of contraception.