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A 6 Month Study Comparing Latanoprost With Timolol in Patients With Open Angle Glaucoma or Ocular Hypertension

Last updated on March 14, 2019

FOR MORE INFORMATION
Study Location
Pfizer Investigational Site
La Jolla, California, 92093-0946 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Glaucoma, Open Angle Glaucoma, Ocular Hypertension
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
40 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
Show details

- Unilateral or bilateral primary open angle glaucoma, capsular glaucoma, pigmentary
glaucoma or ocular hypertension.

- Open angle glaucoma appearing more than 6 months after cataract surgery is recognized
as primary open angle glaucoma. (individuals requiring treatment bilaterally must
fulfill eligibility criteria for both eyes.)

- IOP of 22mmHg or higher obtained during the pre-study period.

- Patients currently not treated or on single-drug treatment for the elevated IOP are
eligible after a medication free period (wash-out) of:

1. 3 weeks for B-adrenergic antagonists

2. 2 weeks for adrenergic agonists

3. 5 days for cholinergics and oral carbonic anhydrase inhibitors.

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details

- History of acute angle closure.

- Severe trauma at any time.

- Intraocular surgery or argon laser trabeculoplasty within 6 months.

- Current use of contact lenses.

- History of severe dry eye syndrome.

- Ocular inflammation/infection with three months of inclusion.

- Any condition preventing reliable applanation tonometry.

- Unacceptable finding at pre-study ocular examination as specified in the Case Report
Forms.

- In Investigator regards monotherapy insufficient with respect to optic nerve head
and/or visual field status.

- Treatment of elevated IOP with any topical B-adrenergic antagonist regularly for a
period longer than 3 months and/or treatment at any time during 6 months prior to
study start.

- Cardiac failure, sinus bradycardia, second and third degree of atrio-ventricular
block.

- Bronchial asthma, history of bronchial asthma or chronic obstructive pulmonary
disease.

- Having participated in any other clinical study within the last month.

NCT00751127
Pfizer
Completed
A 6 Month Study Comparing Latanoprost With Timolol in Patients With Open Angle Glaucoma or Ocular Hypertension

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[email protected]

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