Cumulative Irritation Test

• Other: AN2718
  
  AN2718 Cream SF Vehicle, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Cream SF, 0.3%, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Cream SF, 1%, Daily for up to 21 days
• Other: AN2718
  
  AN2718 Gel Vehicle, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Gel, 1.5%, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Gel, 2.5%, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Gel, 5%, Daily for up to 21 days
• Drug: AN2718
  
  AN2718 Gel, 7.5%, Daily for up to 21 days
• Other: Sodium Lauryl Sulfate
  
  Sodium Lauryl Sulfate, 0.5%, Daily for up to 21 days
  Other Name: SLS

• Experimental: A
  
  AN2718 Cream SF Vehicle
  Intervention: Other: AN2718
• Experimental: B
  
  AN2718 Cream SF, 0.3%
  Intervention: Drug: AN2718
• Experimental: C
  
  AN2718 Cream SF, 1%
  Intervention: Drug: AN2718
• Experimental: D
  
  AN2718 Gel Vehicle
  Intervention: Other: AN2718
• Experimental: E
  
  AN2718 Gel, 1.5%
  Intervention: Drug: AN2718
• Experimental: F
  
  AN2718 Gel, 2.5%
  Intervention: Drug: AN2718
• Experimental: G
  
  AN2718 Gel, 5%
  Intervention: Drug: AN2718
• Experimental: H
  
  AN2718 Gel, 7.5%
  Intervention: Drug: AN2718
• Active Comparator: I
  
  Sodium Lauryl Sulfate, 0.5%
  Intervention: Other: Sodium Lauryl Sulfate

Inclusion Criteria:

Subjects must meet all of the following criteria for inclusion in the study.

1. Healthy volunteers of either sex, at least 18 years of age or older.
2. Females must be of non-childbearing potential (i.e., post-menopausal or surgically sterile [bilateral oophorectomy and/or total hysterectomy]). All females must submit to a urine pregnancy test and have a negative result at Day 1 and at the final study visit.
3. Subjects may be of any skin type or race providing their degree of skin pigmentation does not interfere with making readings of skin reactions.
4. Willingness to follow the study procedures and complete the study.
5. Written informed consent obtained.

Exclusion Criteria:

1. Any skin disease that would in any way confound interpretation of the study results. Atopic dermatitis/eczema, psoriasis will be excluded.
2. Chronic asthma will be excluded.
3. Pregnant or nursing mothers.
4. A history of sensitivity to any component of any of the formulations.
5. Use of chronic medications (such as antihistamines, corticosteroids, analgesics and anti-inflammatories) for one week before and during the study.