- Healthy adult subjects.
- Extensive or ultra-rapid metabolizers of CYP2D6 substrates, predicted by genotype.
- Existence of significant medical conditions that would impact study results or pose
unacceptable risks to study subjects.
- Pregnant or nursing females or females of childbearing potential who are unwilling or
unable to use an acceptable method of contraception.
- Use of prescription or nonprescription drugs and dietary supplements within 7 days
prior to the first dose of study medication.