Safety And Pharmacokinetics Study Of PF-04287881 In Healthy Adults

• Drug: PF-04287881
  
  75 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 75 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  150 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 150 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  300 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 300 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  750 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 750 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  1000 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 1000 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  1250 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 1250 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  1500 mg oral dose (prepared solution) given once
• Drug: Placebo
  
  placebo to match 1500 mg oral dose (prepared solution), given once
• Drug: PF-04287881
  
  1000 mg based on safety and PK from previous cohorts; oral dose (prepared solution) given once

• Experimental: Cohort 1
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 2
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 3
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 4
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 5
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 6
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 7
  
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 8
  
  Japanese volunteers, low dose previously tested (based on PK)
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 9
  
  Japanese volunteers, intermediate dose previously tested (based on PK)
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo
• Experimental: Cohort 10
  
  Japanese volunteers, high dose previously tested (based on safety)
  Interventions:
  

  • Drug: PF-04287881
  • Drug: Placebo

Inclusion Criteria:

• Volunteers willing and able to be confined to the Clinical Research Unit and comply with study schedule.
• Women of non-childbearing potential only.
• Japanese subjects muct have 4 Japanese grandparents who were born in Japan.

Exclusion Criteria:

• Previous antibiotic use within 14 days prior to dosing.
• Use of antibiotics during hospitalization within 90 days prior to dosing.
• History of sensitivity to macrolides or ketolides.
• Presence of clinically significant eye conditions (other than corrective lenses).