Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Major Abdominal Surgery

• Biliary Tract Surgical Procedures
• Pancreaticoduodenectomy
• Esophagectomy
• Colectomy
• Gastrectomy

• Drug: Tranexamic acid + Standard of Care
  
  Tranexamic acid given slowly intravenously (15 mg/kg body weight) 15 minutes before surgery followed by a second dose at three hour interval from first dose and third dose at three hour interval from the second + standard of care (Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss)
• Procedure: Standard of Care
  
  Standard of care includes the routine surgical and anesthetic techniques being utilized to control blood loss

• Experimental: A
  
  end of the operation and on the mornings of the first, second, fourth and seventh postoperative days.
  Intervention: Drug: Tranexamic acid + Standard of Care
• B
  
  Standard of Care
  Intervention: Procedure: Standard of Care

Inclusion Criteria:

• Patient undergoing major abdominal surgery (Biliary strictures, Pancreatico-duodenectomy, Esophagectomy, Total proctocolectomy, Hemicolectomy, Gastrectomy, Other major abdominal surgeries with similar expected blood loss)

Exclusion Criteria:

• Patients with a platelet count less than 100, 000/mm3 or history of thrombocytopenia.
• Patients with known coagulopathy.
• Patients with anemia (hemoglobin levels less than 8 mg/dl)
• Patients with documented DVT or PE at screening or in past three months.
• Patients with any associated major illness (e.g., severe cardiac or respiratory disease).
• Anticoagulants (other than LMWH or heparin in prophylactic doses to prevent deep vein thrombosis), direct thrombin inhibitors or thrombolytic therapy administered or completed within last week