A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.

• Rheumatoid Arthritis
• Healthy Volunteers

• Drug: CE-224,535
  
  one 250mg tablet, once in the morning in fasted state
  Other Name: Part 1;Treatment A
• Drug: CE-224,535
  
  2x250 mg tablets, once in the morning, in fasted state
  Other Name: Part 1;Treatment B
• Drug: CE-224,535
  
  4x250mg tablets, once in the morning, in fasted state
  Other Name: Part 1;Treatment C
• Drug: CE-224,535
  
  2x250mg tab, once in the morning, after being fed a high fat meal
  Other Name: Part 1;Treatment D
• Drug: CE-224,535
  
  4x125 mg tabs, once in the morning, in the fasted state. This arm will only occur as part of Part 2, if needed, pending results of Part 1.
  Other Name: Part 2;Treatment E
• Drug: CE-224,535
  
  4x125 mg IR once in the morning after being fed a high fat meal
  Other Name: Part 2; Treatment F
• Drug: CE 224,535
  
  2x250 mg controlled release formulation 5 tabs once in the morning in the fasted state
  Other Name: Part 2; Treatment G
• Drug: CE 224,535
  
  2x250 mg controlled release formulation 5 once in the morning after being fed a high fat meal
  Other Name: Part 2; Treatment H

• Experimental: Part1; controlled release formulation 4; 250 mg
  
  one 250 mg controlled release tablet, once in the morning, in fasted state
  Intervention: Drug: CE-224,535
• Experimental: Part1; controlled release formulation 4; 500 mg
  
  2x250 mg, once in the morning, in fasted state
  Intervention: Drug: CE-224,535
• Experimental: Part 1; controlled release formula 4; 1000 mg
  
  4x250 mg tabs, once in the morning, in fasted state
  Intervention: Drug: CE-224,535
• Experimental: Part 1; controlled release formulation 4; 500 mg FED
  
  2x250 mg, once in the morning , in fed state
  Intervention: Drug: CE-224,535
• Experimental: Part 2; IR formulation 500mg
  
  4x125 mg tab of current formulation , once in the morning in the fasted state. This arm will occur as Part 2, only as needed, pending results of Part 1
  Intervention: Drug: CE-224,535
• Experimental: Part 2; IR formulation, 500 mg FED
  
  4x125 mg once in the morning in the fed state. This arm will occur as part of Part 2,only as needed, pending results of Part 1.
  Intervention: Drug: CE-224,535
• Experimental: Part 2; controlled release formulation 5;500 mg, FASTED
  
  2x250 controlled release formulation 5 tabs once in the morning in the fasted state. This arm will only occur as part of Part 2, pending results of Part 1.
  Intervention: Drug: CE 224,535
• Experimental: Part 2; controlled release formulation 5;500 mg, FED
  
  2x250 mg controlled release formulation 5 tabs once in the morning in the fed state. This arm will only occur as part of Part 2 pending results of Part 1
  Intervention: Drug: CE 224,535

Inclusion Criteria:

• aged 18-55 and healthy

Exclusion Criteria:

• severe chronic or uncontrolled medical or psychiatric conditions, including drug abuse
• pregnant or wanting to become pregnant