A 2-Year Phase 3 Study Of CP-690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate

• Drug: CP-690,550
  
  Oral tablets administered at 5 mg BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.
  Other Name: Double-blind, placebo-controlled period
• Drug: CP-690,550
  
  Oral tablets administered at 5 mg BID daily through the end of the study during the double-blind, active-extension period.
  Other Name: Double-blind, Active Extension Period
• Drug: CP-690,550
  
  Oral tablets administered at 10 mg BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.
  Other Name: Double-blind, placebo-controlled period
• Drug: CP-690,550
  
  Oral tablets administered at 10 mg BID daily through the end of the study during the double-blind, active-extension period.
  Other Name: Double-blind, Active Extension Period
• Drug: Placebo
  
  Oral placebo tablets administered BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.
  Other Name: Double-blind, placebo-controlled period
• Drug: Placebo
  
  Oral placebo tablets administered BID daily for 6 months (nonresponders advance to second intervention at 3 months) during the double-blind, placebo-controlled period.
  Other Name: Double-blind, Active Extension Period
• Drug: CP-690,550
  
  Oral tablets administered at 10 mg BID daily through the end of the study during the double-blind, active-extension period.
  Other Name: Double-blind, placebo-controlled period

• Experimental: Sequence 1
  
  Interventions:
  

  • Drug: CP-690,550
  • Drug: CP-690,550
• Experimental: Sequence 2
  
  Interventions:
  

  • Drug: CP-690,550
  • Drug: CP-690,550
• Placebo Comparator: Sequence 3
  
  Interventions:
  

  • Drug: Placebo
  • Drug: CP-690,550
• Placebo Comparator: Sequence 4
  
  Interventions:
  

  • Drug: Placebo
  • Drug: CP-690,550

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Inclusion Criteria:

• Adults with moderate to severe rheumatoid arthritis on a stable dose of methotrexate

Exclusion Criteria:

• Pregnancy, severe acute or chronic medical conditions, including serious infections or clinically significant laboratory abnormalities.