- The patient has a diagnosis of Rheumatoid Arthritis based on the American College of
Rheumatology (ACR) 1987 Revised Criteria.
- The patient has active disease as defined by both >=4 tender or painful joints on
motion and >= 4 joints swollen; and either an erythrocyte sedimentation rate (ESR) >
28 mm or a C-reactive protein (CRP) concentration > 7 mg/dL.
- Patient had an inadequate response to at least one disease modifying antirheumatic
drug (traditional or biologic) due to lack of efficacy or toxicity.
- Patient must remain on at least one background traditional disease modifying
- No evidence of inadequately treated latent or active infection with Mycobacterium
- Blood dyscrasias including confirmed: Hemoglobin blood cell count
- History of any other rheumatic autoimmune disease other than Sjogren's syndrome.
- No malignancy or history of malignancy.
- History of infection requiring hospitalization, parenteral antimicrobial therapy, or
as otherwise judged clinically significant by the investigator, within the 6 months
prior to the first dose of study drug.