- Patients with advanced cancer that is resistant to standard therapy or for which no
standard therapy is available
- Patients with acute T cell leukemia/lymphoblastic lymphoma that is resistant to
standard therapy or for which no standard therapy is available
- Men and women >16 years old
- Prior treatment with a gamma secretase inhibitor for treatment of cancer
- Patients taking Tamoxifen
- Patients with active graft versus host disease
- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)
related illness
- Patients who are pregnant or breast feeding
- Patients with clinical evidence of central nervous system disease