depressive disorder based on DSM-IV criteria, with/without current co-morbid anxiety
disorder; 4. Has two or more episodes of depression (including the current episode) in the
past 5 years, with an interval of at lease 2 months between the end of the previous episode
and the beginning of the current episode. 5. The baseline score of 17-item Hamilton Rating
Scale for Depression (HAM-D)>=17; 6 If female of childbearing potential, have a negative
urine pregnancy test at baseline, if appropriate, and use a medically acceptable method of
contraception throughout the study.
before;3.Clinically significant renal or hepatic disease or any other medical disease that,
in the opinion of the investigator, might compromise the study, including seizure disorder
(with the exception of a single childhood febrile seizure); 4.Alcohol or drug abuse within
the last year;5.A recent history of myocardial infarction or unstable heart disease (within
6 months of baseline);6.Bipolar disorder;7.For female, known or suspected pregnancy or
breast feeding;8.Use of a monoamine oxidize inhibitor (MAOI) within 14 days of baseline;
use of any investigational drug within 30 days of baseline.