- Confirmed advanced solid tumors unresponsive to currently available therapies, or for
which there is no standard therapy.
- Adequate coagulation, liver and renal function.
- Candidate for DCE-MRI evaluation.
- ECOG (Eastern Cooperative Oncology Group) performance status 0 or 1.
- Evidence of bleeding problems.
- Uncontrolled hypertension.
- Certain gastrointestinal problems including fistula and abscess.
- Patients with primary brain cancer.