- Healthy male and/or female subjects, not of child bearing potential.
- Age 18-55 inclusive
- Total body weight >50 kg.
- Evidence or history of clinical significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
- History of orthostatic blood pressure changes or orthostatic symptoms
- Greater than 7 drinks of alcohol per week for women and greater than 14 drinks per
week for men
- Smoking more than 5 cigarettes per day