Study To Investigate The Effectiveness Of Pregabalin For Management Of Patients Undergoing Total Hip Replacement

• Drug: Placebo
  
  Placebo as an adjunct to standard of care
• Drug: Pregabalin
  
  75 mg BD for 14 days

• Placebo Comparator: Placebo
  
  Placebo as an adjunct to standard of care
  Intervention: Drug: Placebo
• Active Comparator: Pregabalin
  
  Pregabalin as an adjunct to standard of care
  Intervention: Drug: Pregabalin

Inclusion Criteria:

• The patient is undergoing a routine (i.e., expected to be uncomplicated) total primary or secondary hip replacement surgery performed under a standardized regimen of spinal anesthesia, and is expected to experience moderate to severe post-surgical pain in the absence of post-operative analgesia

Exclusion Criteria:

• The patient is undergoing a revision to a previous hip replacement procedure, hip replacement procedure further to a road traffic accident with multiple injuries, or a procedure expected to last longer than 4 hours
• The patient has a history of uncontrolled chronic disease or a concurrent clinically significant illness or medical condition, which in the Investigator's opinion, would contraindicate study participation or confound interpretation of the results