- Histologically or cytologically confirmed advanced measurable or evaluable solid
tumors unresponsive to currently available therapies, or for which there is no
curative therapy
- Eastern Cooperative Oncology Group (ECOG) performance status 0 and 1
- Life expectancy more than12 weeks
- Adequate bone marrow, liver and renal function
- Known brain metastasis
- Chemotherapy, radiotherapy, or any investigational cancer therapy within 4 weeks of
start of screening procedures
- Major surgical procedure within 4 weeks of start of screening procedures
- Active bleeding disorder, including gastrointestinal bleeding, as evidenced by
hematemesis, significant hemoptysis or melena in the past 6 months