- Healthy male and/or female subjects between the ages of 18 and 55 years, inclusive,
(Healthy is defined as no clinically relevant abnormalities identified by a detailed
medical history, full physical examination, including blood pressure and pulse rate
measurement, normal 12-lead ECG and clinical laboratory tests)
- History of risk factors for QT prolongation or torsades de pointes (eg, organic heart
disease, congestive heart failure, hypokalemia, hypomagnesemia, congenital long QT
syndrome, myocardial ischemia or infarction).
- Use of tobacco- or nicotine-containing products in excess of the equivalent of 5
cigarettes per day
- Use of prescription or nonprescription drugs, vitamins and dietary supplements within
7 days or 5 half-lives (whichever is longer) prior to the first dose of trial
medication.