Study Evaluating The Safety And Tolerability Of Administration Of Single Oral Doses Of SAM-760 To Healthy Subjects

• Drug: SAM-760
  
  SAM-760 capsule, 0.25, 0.75, 2.25, 5, 10, 15, 20, 25, 35 and 45mg, single dose, 1 day
• Drug: Placebo of SAM-760
  
  SAM-760 matching placebo capsule, single dose, 1 day,
  Other Name: Placebo
• Drug: ketoconazole
  
  Ketoconazole oral tablets, 200 mg bid, 14 days
  Other Name: ketoconazole interaction arm

• Experimental: 1
  
  active arm/healthy young
  Intervention: Drug: SAM-760
• Placebo Comparator: 2
  
  placebo arm
  Intervention: Drug: Placebo of SAM-760
• 3
  
  ketoconazole interaction evaluation
  Intervention: Drug: ketoconazole

Inclusion Criteria:

• Men or women of non-childbearing potential aged 18 to 50 years inclusive (healthy young subjects) and > 65 years (healthy elderly subjects) at screening.
• Body mass index (BMI) in the range of 18 to 32 kg/m2 and body weight >= 50 kg.

Exclusion Criteria:

• Presence or history of any disorder that may prevent the successful completion of the study.
• Any surgical or medical condition that may interfere with the absorption, distribution, metabolism, or excretion of the investigational drug or placebo.