Study of CP-690,550 Versus Placebo In Rheumatoid Arthritis Patients On Background Methotrexate With Inadequate Response To Tumor Necrosis Factor (TNF) Inhibitors

• Drug: CP-690,550
  
  Oral tablets administered at 5 mg BID daily for 6 months during the double-blind, placebo-controlled period.
• Drug: CP-690,550
  
  Oral tablets administered at 10 mg BID daily for 6 months during the double-blind, placebo-controlled period.
• Drug: Placebo
  
  Oral placebo tablets administered BID daily during the first 3 months of the double-blind, study period.
  Other Name: double-blind, placebo-controlled phase
• Drug: CP-690,550
  
  Oral tablets administered at 5 mg BID daily during the second 3 months of the double-blind, study period.
  Other Name: double-blind, extension phase
• Drug: Placebo
  
  Oral placebo tablets administered BID daily during the first 3 months of the double-blind, placebo-controlled period.
  Other Name: double-blind, placebo-controlled phase
• Drug: CP-690,550
  
  Oral tablets administered at 10 mg BID daily during the second 3 months of the double-blind, study period.
  Other Name: double-blind, extension phase

• Experimental: Sequence 1
  
  Intervention: Drug: CP-690,550
• Experimental: Sequence 2
  
  Intervention: Drug: CP-690,550
• Placebo Comparator: Sequence 3
  
  Interventions:
  

  • Drug: Placebo
  • Drug: CP-690,550
• Placebo Comparator: Sequence 4
  
  Interventions:
  

  • Drug: Placebo
  • Drug: CP-690,550

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Inclusion Criteria:

• Adults with moderate to severe rheumatoid arthritis on a stable dose of methotrexate who have inadequate response to Tumor Necrosis Factor (TNF) inhibitors.

Exclusion Criteria:

• Pregnancy, severe acute or chronic medical conditions, including serious infections or clinically significant laboratory abnormalities.