1. Patients with untreated newly diagnosed and genetically proven APL (leukemic cells at
diagnosis with the t(15;17) and/or the PML/RARα rearrangement by RT-PCR; the presence
of additional cytogenetic lesions is not considered an exclusion criterion) with
intermediate and high risk disease.
2. Male and female patients age > 18 years and
1. Low risk patients (WBC 40 x 109/L).
2. Absence of PML-RAR ? rearrangement in leukemic cells after successful RNA extraction
and amplification of control gene.
3. Pretreated APL.