Eligibility criteria
Condition
Knee Osteoarthritis, Hip Osteoarthritis
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Osteoarthritis of the knee or hip based on American College of Rheumatology criteria
with a radiographic (X ray) confirmation (a Kellgren Lawrence x-ray grade of ≥2);
Exclusion criteria
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- Body mass index (BMI) of >39 kg/m2;
- Pregnancy or intent to become pregnant
- Planned surgical procedure during the duration of the study
- History of clinically significant cardiovascular, central nervous system or
psychiatric disease
- Previous exposure to exogenous NGF or to an anti NGF antibody;
- Use of biologics other than study medication, Live or live-attenuated intranasal
vaccines (eg, Flumist), are allowable exceptions