- Males or females of non-childbearing potential (age 50 and over for Alzheimer's
disease patients; 21-45 for healthy volunteers)
- For patients with Alzheimer's Disease: Diagnosis of probable Alzheimer's disease,
consistent with criteria from both National Institute of Neurological and Communicable
Disease and Stroke and Alzheimer's Disease and Related Disorders Association
(NINCDS-ADRDA) and Diagnostic and Statistical Manual of Mental Disorders (DSM IV)
- Mini-mental status exam score greater than or equal to 20
- Rosen-Modified Hachinski Ischemia Score of
- On stable dose of background cholinesterase inhibitor or memantine at least 3 months
prior to enrollment
- Diagnosis or history of other demential or neurodegenerative disorders
- Diagnosis or history of clinically significant cerebrovascular disease
- Specific findings on magnetic resonance imaging (MRI); cortical infarct, micro
hemorrhage, multiple white matter lacunes, extensive white matter abnormalities
- History of autoimmune disorders
- History of allergic or anaphylactic reactions