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Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

Last updated on February 28, 2019

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Study Location
Pfizer Investigational Site
Glendale, California, 91206 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Alzheimer's Disease
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
21 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Males or females of non-childbearing potential (age 50 and over for Alzheimer's
disease patients; 21-45 for healthy volunteers)

- For patients with Alzheimer's Disease: Diagnosis of probable Alzheimer's disease,
consistent with criteria from both National Institute of Neurological and Communicable
Disease and Stroke and Alzheimer's Disease and Related Disorders Association
(NINCDS-ADRDA) and Diagnostic and Statistical Manual of Mental Disorders (DSM IV)

- Mini-mental status exam score greater than or equal to 20

- Rosen-Modified Hachinski Ischemia Score of

- On stable dose of background cholinesterase inhibitor or memantine at least 3 months
prior to enrollment

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details

- Diagnosis or history of other demential or neurodegenerative disorders

- Diagnosis or history of clinically significant cerebrovascular disease

- Specific findings on magnetic resonance imaging (MRI); cortical infarct, micro
hemorrhage, multiple white matter lacunes, extensive white matter abnormalities

- History of autoimmune disorders

- History of allergic or anaphylactic reactions

NCT01005862
Pfizer
Completed
Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

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[email protected]

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