- Meets the American College of Rheumatology (ACR) 1987 revised criteria for
classification of Rheumatoid Arthritis (RA) for at least 6 months prior to screening
- Active RA as defined by >= 5 swollen and >= 5 tender joints (28-joint count) and at
least 1 of the following: C-reactive protein >= 10 mg/L or Erythrocyte Sedimentation
Rate >= 28 mm/h
- Must be seropositive as defined by a documented history of rheumatoid factor (RF) or
anti-cyclic citrullinated peptide (anti-CCP) positivity
- Must be receiving a stable route and dose of methotrexate (up to 25 mg weekly)
- Any significant health problem other than rheumatoid arthritis
- Any clinically significant laboratory abnormalities
- Any prior use of B cell-depleting therapy