Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients
NCT01019551
ABOUT THIS STUDY
FOR MORE INFORMATION
Contact a representative by phone, email, or visiting the study website. Please see the references below:
Pfizer Clinical Trials Contact Center
1-800-718-1021
Adult Trials: 18+ Years
- HIV-1 infection, documented by any licensed ELISA test kit and confirmed by Western Blot at any time prior to study entry. HIV-1 culture, HIV-1 antigen, plasma HIV-1 RNA, or a second antibody test by a method other than ELISA is acceptable as an alternative confirmatory test
- 18 ≤ Age ≤ 70 years
- At least 3 years of suppressive ART without any interruption (less than one month cumulative),
- ART treatment unchanged in the 3 months prior to screening
- One HIV plasma viral load (RNA) documented at least 3 years prior to entry, and at least 2 HIV plasma viral loads (RNA) documented per year thereafter
- HIV plasma viral load (RNA) ≤ 500 copies/ml at least 3 years prior to entry and HIV plasma viral load ≤ 500 copies/ml for ≥ 90% of the measures thereafter
- HIV plasma viral load (RNA) below the limit of detection for all values within the past year. Note: the assay used must have a lower limit of detection of 75 copies/ml or less
- CD4+ count ≥ 350 cells/mm3 within 60 days of entry
- 10 ≤ Proviral DNA ≤ 1000 copies/106 PBMCs within 60 days of entry
- Documented laboratory values: Haemoglobin ≥ 10 g/dl, Platelets ≥ 100,000 per microliter, Hepatic transaminases ≤ 2.5 x ULN, Creatinine clearance ≥ 50 ml/min by the Cockcroft-Gault equation
- All subjects must agree not to participate in the conception process (e.g. active attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization), and if participating in sexual activity that could lead to pregnancy, the subject/partner must use at least two reliable forms of contraceptives (condoms, with or without spermicidal agent, a diaphragm or cervical cap with spermicide, an IUD, or hormone-based contraception), while receiving study treatment and for 6 weeks after stopping study treatment
- Ability and willingness to provide informed consent.
- Sexually active men and women who will not practice at least one form of barrier birth
control (male partner using condoms, female partner using condoms, other barrier
contraception, etc)
- Pregnancy as documented by a urine pregnancy test, or lactating women
- Hepatitis B antigen (HBsAg) positive
- Hepatitis C virus (HCV-Ab) positive or HCV RNA detectable
- Previous use of an integrase inhibitor (ie raltegravir) or a CCR5 inhibitor (ie
maraviroc, vicriviroc). Use of raltegravir for non-treatment failure indications such
as intensification and toxicity switches is allowed, provided that 1) virologic
suppression was maintained before, during and after raltegravir treatment and 2) the
patient has not received raltegravir treatment in the 6 months prior to study entry.
- Previous immunologic therapeutic intervention (e.g. IL-2, IL-7) within the past year
- Participation in another clinical drug or device trial where the last dose of drug was
within the past 30 days or an investigational medical device is currently implanted
- Diagnosis of cancer within the last 5 years (except basal cell cutaneous cancers and
cutaneous KS not requiring systemic therapy)
- Co-morbid condition with an expected survival less than 12 months
- History of hypersensitivity to vaccination
- History of autoimmune disease, such as systemic lupus erythematosis (SLE) or
Hashimoto's thyroiditis
- Active drug or alcohol use or dependence that, in the opinion of the center
investigator, would interfere with adherence to study requirements.
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| Descriptive Information | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Brief Title ICMJE | Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients | |||||||||
| Official Title ICMJE | International, Multicenter, Randomized, Non-comparative Controlled Study of Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients With Long-term Viral Suppression | |||||||||
| Brief Summary | Viral eradication in selected HIV-infected patients is possible with intensive antiretroviral therapy plus immunomodulation | |||||||||
| Detailed Description | The overall strategy of the ERAMUNE 01 Trial is to treat selected patients with an optimal synergistic antiretroviral regimen plus one or more immunomodulating agents. Among immunomodulating treatments the candidates include therapies from two functional classes: 1) agents that target actively replicating cells and 2) agents activating latently infected cells31. The novelty of this approach is three-fold: first, the use of highly potent antiretroviral therapy combining drugs with different HIV enzymes targets or receptors and different penetrations in cells, with the aim to suppress virus to truly undetectable levels as measured by the most sophisticated viral quantification techniques; secondly, the addition of an immunomodulatory therapy that specifically targets viral reservoirs to this intensification strategy; and lastly, the rigorous selection of patients having already a low HIV reservoir as measured by peripheral blood HIV DNA content. To our knowledge, this type of strategy has not been implemented. We believe this strategy is feasible. | |||||||||
| Study Type ICMJE | Interventional | |||||||||
| Study Phase ICMJE | Phase 2 | |||||||||
| Study Design ICMJE | Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open Label) Primary Purpose: Treatment | |||||||||
| Condition ICMJE | HIV-1 Infection | |||||||||
| Intervention ICMJE |
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| Study Arms ICMJE |
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| Publications * |
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* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. | ||||||||||
| Recruitment Information | ||||||||||
| Recruitment Status ICMJE | Completed | |||||||||
| Actual Enrollment ICMJE | 29 | |||||||||
| Original Estimated Enrollment ICMJE | 28 | |||||||||
| Actual Study Completion Date ICMJE | February 2013 | |||||||||
| Actual Primary Completion Date | July 2012 (Final data collection date for primary outcome measure) | |||||||||
| Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion Criteria:
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| Sex/Gender ICMJE |
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| Ages ICMJE | 18 Years to 70 Years (Adult, Older Adult) | |||||||||
| Accepts Healthy Volunteers ICMJE | No | |||||||||
| Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | |||||||||
| Listed Location Countries ICMJE | France, Italy, Spain, United Kingdom | |||||||||
| Removed Location Countries | ||||||||||
| Administrative Information | ||||||||||
| NCT Number ICMJE | NCT01019551 | |||||||||
| Other Study ID Numbers ICMJE | ORVACS 010 | |||||||||
| Has Data Monitoring Committee | Yes | |||||||||
| U.S. FDA-regulated Product | Not Provided | |||||||||
| IPD Sharing Statement ICMJE | Not Provided | |||||||||
| Responsible Party | Objectif Recherche Vaccins SIDA | |||||||||
| Study Sponsor ICMJE | Objectif Recherche Vaccins SIDA | |||||||||
| Collaborators ICMJE |
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| Investigators ICMJE |
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| PRS Account | Objectif Recherche Vaccins SIDA | |||||||||
| Verification Date | June 2013 | |||||||||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP | ||||||||||