- Male or female (women of non-childbearing potential) subjects between the ages of 40
and 80 years, inclusive with a diagnosis of moderate COPD (GOLD, 2007 update) and who
meet the following criteria for GOLD stage II disease
- Body Mass Index (BMI) of less than 35.5 kg/m2; and a total body weight >40 kg (88
lbs).
- Current smokers, or ex-smokers who have abstained from smoking for at least 6 months
- Subjects having more than 2 exacerbations requiring treatment with oral steroids or
hospitalization for the treatment of COPD in the previous year.
- History of lower respiratory tract infection or significant disease instability during
the month preceding screening or during the period between screening and
randomization.