Eligibility criteria
Condition
Major Depressive Disorder
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Primary Diagnosis of Major Depressive Disorder
- Hamilton Psychiatric Rating Scale for Depression-17-Item score of greater than or
equal to 14 at baseline
Exclusion criteria
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- Current psychoactive substance abuse or dependence, manic episode, or a lifetime
diagnosis of bipolar or psychotic disorder
- Potentially violent to others or is at significant risk for suicide
- History or current evidence of gastrointestinal disease or history of surgery known to
interfere with absorption or excretion
- Known presence of raised intraocular pressure or history of narrow angle glaucoma