Clinical Study Of Eplerenone In Japanese Patients With Chronic Heart Failure

• Drug: Eplerenone
  
  Eplerenone 25 mg once every other day, 25mg once daily or 50 mg once daily
• Drug: Placebo
  
  Placebo once daily or every once daily

• Experimental: Eplerenone arm
  
  Add on standard heart failure therapy
  Intervention: Drug: Eplerenone
• Placebo Comparator: Placebo arm
  
  Add on standard heart failure therapy
  Intervention: Drug: Placebo

Inclusion Criteria:

• Japanese chronic systolic heart failure patients with LVEF =<30% by echocardiography and NYHA II or more
• Patients who receive standard therapy (Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blocker or diuretic)

Exclusion Criteria:

• Patients with a myocardial infarction, stroke, cardiac surgery or percutaneous coronary intervention within 30 days prior to randomization.
• Patients with serum potassium >5.0 mmol/L or eGFR <30 ml/min/1.73 m2.