- healthy male subjects between the ages of 18 and 50 years inclusive. (healthy is
defined as no clinically relevant abnormalities identified by a detailed medical
history, full physical examination including blood pressure and pulse rate
measurement, 12-lead ECG and clinical laboratory tests)
- Body Mass Index (BMI) of 17.5 to 30.5kg/m2l and a total body weight of between 50 and
100kg inclusive.
- Evidence of a personally signed and dated informed consent document indicating that
the subject (or a legally acceptable representative) has been informed of all
pertinent aspects of the trial.
- Evidence or history of clinically significant haematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, genitourinary, psychiatric, neurologic or
allergic disease (including drug allergies, but excluding untreated, symptomatic,
seasonal allergies at time of dosing)
- History of febrile illness within 5 days prior to the first dose a positive urine drug
screen