- For Healthy adult volunteers: healthy male and/or female subjects of non child bearing
potential between the ages of 18 and 55 years, inclusive. (Healthy is defined as no
clinically relevant abnormalities identified by a detailed medical history, full
physical examination, including blood pressure and heart rate measurement, 12 lead ECG
and clinical laboratory tests.)
- For Healthy Elderly volunteers: healthy male and/or female subjects of non child
bearing potential between the ages of 65 and 85 years, inclusive. Subjects must be in
reasonably good health as determined by the investigator based on a detailed medical
history, full physical examination (including blood pressure and pulse rate
measurement), 12 lead ECG and clinical laboratory tests. Subjects with mild, chronic,
stable disease (eg, controlled hypertension, non-insulin dependent diabetes,
osteoarthritis) may be enrolled if deemed medically prudent by the investigator. In
order to ensure an age range relevant to the Alzheimer's Disease (AD) population, no
more than 30% of subjects enrolled in any cohort may be less than 70 years of age.
- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease (including drug allergies, but excluding untreated, asymptomatic,
seasonal allergies at time of dosing).