- Subjects must have experienced a myocardial infarction (STEMI) within the previous 24
hours confirmed by symptoms and ECG.
- Subjects with a known low ejection fraction of less than 40% or any previous history
of heart failure.
- Subjects treated with eplerenone or other aldosterone antagonists within the past 1
- The subject has uncontrolled hypotension (SBP
- Subjects with eGFR ?30ml/min (based on admission serum creatinine and the MDRD
formula) or serum creatinine ?220µmol/L.