Eligibility criteria
Condition
Hepatocellular Carcinoma
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Locally advanced or metastatic HCC
- Failure of one prior antiangiogenic therapy including sorafenib, bevacizumab and
brivanib.
- Child-Pugh Class A or B (score 7 only) disease.
Exclusion criteria
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- Prior treatment of advanced HCC with more than one prior first-line systemic therapy.
- Any prior local therapy within 2 weeks of starting the study treatment.
- Presence of hepatic encephalopathy and/or clinically relevant ascites.
- Presence of main portal vein invasion by HCC.