- Males and females, 18 to 50 years old at the time of consent.
- Documented diagnosis of ADPKD (PKD-1 or PKD-2 genotypes allowed).
- Total kidney volume ≥ 750 cc, as measured by centrally evaluated MRI.
- Uncontrolled hypertension (defined as systolic blood pressure ?140 or diastolic blood
pressure ?90 mm Hg).
- Any previous exposure to the bosutinib test article or receipt of other polycystic
kidney disease (PKD) therapies.