- Smokers aged 18 years or above and wanting to stop smoking
- Smokers who have smoked an average of at least 10 cigarettes per day over the last 4
weeks
- Smokers who have tried before to stop smoking at least once with varenicline, and who
took varenicline for at least 2 weeks
- The last attempt to stop smoking must be at least 3 months before entering the study
- Individuals who have not tolerated varenicline well previously, or who have a current
or prior medical or psychiatric history that would make entry into the trial
inadvisable
- Individuals who have previously participated in clinical trials of varenicline
- Individuals who have been participating in another smoking cessation trial within the
last 3 months, or other drug trial within the last 30 days