- Healthy male subjects, inclusive (Healthy is defined as no clinically relevant
abnormalities identified by a detailed medical history, full physical examination,
including blood pressure and pulse rate measurement, 12-lead ECG and clinical
laboratory tests).
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg
- Subjects who are smoking,
- Subjects with evidence of disease,
- Subjects with conditions affecting absorption,
- Subjects with treatment with other investigational drug within 30 days,
- Subjects with history of regular alcohol consumption,
- Subjects with use of prescription, nonprescription drugs and dietary supplement within
28 days,
- Subjects with blood donation of approximately 400 mL within 3 months or 200 mL within
1 month prior to dosing