Eligibility criteria
Condition
Pulmonary Arterial Hypertension
Sex
Females and Males
Age
21-55 years
Inclusion criteria
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- Healthy male subjects and/or women of non-child bearing potential.
- Subjects (because of teratogenic risk of sitaxsentan) between the ages of 21 and 55
years, inclusive.
- Signed informed consent.
Exclusion criteria
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- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease.
- History of significant alcohol and drug use.
- Has hepatic dysfunction.