ABOUT THIS STUDY
- Male and/or female healthy volunteers, age 18 to 55 years. Females must be of non-childbearing potential.
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).
- Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, diet restrictions and other trial procedures.
- Subjects with a supine BP >140 mm Hg systolic or >90 mm Hg diastolic or <100 mm Hg
systolic or <60 mm Hg diastolic based on the average of the triplicate
- Serum potassium >=5.1 mmol/L or <3.5 mmol/L at screening, confirmed by a single repeat
if deemed necessary.
- Estimated GFR <60 mL/min/1.73 m2 using the Cockcroft-Gault formula measurement of the
individual parameters following at least 5 minutes of rest at Screening.
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