Risk of Cancer Among Pantoprazole Users

• Pantoprazole
  
  Patients who received treatment with pantoprazole tablets for at least 240 days within a 12-month period from 2000 through 2003.
  Intervention: Other: Does not apply
• Other proton pump inhibitors
  
  Patients who received treatment with any other proton pump inhibitor for at least 240 days within a 12-month period from 1996 through 2003.
  Intervention: Other: Does not apply

Inclusion Criteria:

• Patients who have used pantoprazole or other proton pump inhibitors, enrollment in the health maintenance organization for at least 6 months, age 18 years or older.

Exclusion Criteria:

• Use of any proton pump inhibitor before study entry, any cancer diagnosis recorded in the medical history, diagnosis of Zollinger-Ellison Syndrome in medical history.