- Healthy males and females of non-childbearing potential between ages of 18 and 55
years, BMI of 18.5 to 30.5 kg/m^2, and weight between 50 and 100 kg, inclusive.
- Type 2 diabetic males and females of non-childbearing potential between ages of 18 and
55 years, BMI of 18.5 to 40.0 kg/m^2, weight between 50 and 150 kg, and HbA1c of
- Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
- Additionally, type 2 diabetic patients who have history of diabetic complications with
significant end-organ damage or pharmacologic treatment for diabetes in addition to