Bioequivalence Study of Doxazosin 4 Mg Orally-Disintegrating Tablet With Or Without Water To Doxazosin 4 Mg Japanese Marketed Immediate Release Tablet Under Fasted Condition

• Drug: Doxazosin 4 mg Japanese marketed IR tablet
  
  Immediate release tablet, 4 mg, single dose
• Drug: Doxazosin 4 mg ODT with water
  
  Orally-disintegrating Tablet , 4 mg, single dose with water
• Drug: Doxazosin 4 mg ODT without water
  
  Orally-disintegrating Tablet , 4 mg, single dose without water

• Experimental: A
  
  Doxazosin 4 mg Japanese marketed IR tablet as a single oral dose under fasted conditions
  Intervention: Drug: Doxazosin 4 mg Japanese marketed IR tablet
• Experimental: B
  
  Doxazosin 4 mg ODT with water as a single oral dose under fasted conditions
  Intervention: Drug: Doxazosin 4 mg ODT with water
• Experimental: C
  
  Doxazosin 4 mg ODT without water as a single oral dose under fasted conditions
  Intervention: Drug: Doxazosin 4 mg ODT without water

Inclusion Criteria:

• Japanese healthy male subjects

Exclusion Criteria:

• Baseline orthostatic hypotension defined as a ?20 mm Hg reduction in SBP, a ?10 mm Hg reduction in DBP and/or the development of significant postural symptoms (dizziness, lightheadedness, vertigo) when going from the supine to standing position.